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This activity demonstrates the specificity of viral vectors for target cells in gene therapy delivery methods using two approaches: 1) STYROFOAM® models demonstrate viral ligand binding to receptor proteins on the surface of target cells; 2) Learners use paper models of viruses and cells to find the appropriate match between viral ligands and cell receptors.
- 10 to 30 minutes
- 10 to 30 minutes
- $10 - $20 per group of students
- Ages 11 - 18
- Activity, Lesson/Lesson Plan, Model
- English
Quick Guide
Materials List (per group of students)
- 2 - 4-inch smooth STYROFOAM® balls
- 2 - 1.5-inch smooth STYROFOAM® balls
- Snap tape, 1/4 to 1/2 yard (can be obtained at any fabric store)
- VELCRO® hook and loop fasteners, one package adhesive-backed circles (can be obtained at any fabric store)
- Hot glue gun
- Spray paint (optional)
- Pages S1 to S6 - enough copies to give one Virus or Cell cut-out to each learner
Subjects
-
Life Sciences
-
Cells
- Cell Structure and Function
-
Diversity of Life
- Viruses and Bacteria
-
Heredity and Genetics
- DNA Structure and Function
- Genetic Engineering
-
Human Body
- Health and Nutrition
- Medicine
-
Cells
-
Physical Sciences
-
Chemistry
- Chemistry of Life
-
Chemistry
Informal Categories
- Model Building
Audience
To use this activity, learners need to:
- see
- read
- touch
Learning styles supported:
- Involves hands-on or lab activities
Other
Components that are part of this resource:
Includes alignment to state and/or national standards:
This resource is part of:
Access Rights:
- Free access
By:
- Carillo, Alayne ; Turner, Vicki ; Stark, Louisa ; Malone, Molly ; Limson, Mel ; Starr, Harmony
Source Collection
- Teach.Genetics
Rights:
- All rights reserved, University of Utah, 2002
Funding Source:
- Science Education Partnership Award (SEPA) from the National Center for Research Resources, a component of the National Institutes of Health, Department of Health and Human Services, 1 R25 RR16291-01